In genetics, a silencer is a DNA sequence capable of binding transcription regulation factors, called repressors. DNA contains genes and provides the template to produce messenger RNA (mRNA). That mRNA is then translated into proteins. When a repressor protein binds to the silencer region of DNA, RNA polymerase is prevented from transcribing the DNA sequence into RNA. With transcription blocked, the translation of RNA into proteins is impossible. Thus, silencers prevent genes from being expressed as proteins.RNA polymerase, a DNA-dependent enzyme, transcribes the DNA sequences, called nucleotides, in the 3' to 5' direction while the complementary RNA is synthesized in the 5' to 3' direction. RNA is similar to DNA, except that RNA contains uracil, instead of thymine, which forms a base pair with adenine. An important region for the activity of gene repression and expression found in RNA is the 3' untranslated region. This is a region on the 3' terminus of RNA that will not be translated to protein but includes many regulatory regions.
Not much is yet known about silencers but scientists continue to study in hopes to classify more types, locations in the genome, and diseases associated with silencers.

View More On Wikipedia.org
  1. CountryGent

    NFA Processing & Coronavirus

    From the American Suppressor Association: NFA Processing & Coronavirus
  2. CountryGent

    Other State  Virginia has a proposed bill outlawing "assault weapons", silencers, and accessories.

    Details on the proposed law here: HB 4021 Assault firearms, certain firearm magazines, trigger activators, & silencers; prohibiting sale, etc.
  3. CountryGent

    ASA Petition

    The American Suppressor Association (ASA) has a petition to the Trump administration to leave silencers alone. Details can be seen here. Just passing it along.
  4. CountryGent

    National  Trump on Gun ‘Silencers’ Like One Used in Virginia Beach Shooting: ‘I Don’t Like Them at All’

    Trump on Gun ‘Silencers’ Like One Used in Virginia Beach Shooting: ‘I Don’t Like Them at All’ Not good.
  5. CountryGent

    New Mailing Address for NFA Forms

    Just a heads up that there is a new mailing address in Oregon for NFA forms 1 and 4. The American Suppressor Association has information here. Updated forms are available for download here. Cheers. National Firearms Act Division P.O. Box 5015 Portland, OR 97208-5015
  6. Joe Link

    National  Smith & Wesson Is Ready to Make Some Noise in Gun Silencers

    Smith & Wesson Is Ready to Make Some Noise in Gun Silencers -- The Motley Fool
  7. CountryGent

    National  Hearing Protection Act Language Incorporated Into Comprehensive Sportsmens Package

    The latest concerning the Hearing Protection Act from the ASA: Hearing Protection Act Language Incorporated Into Comprehensive Sportsmens Package (the Sportsmen’s Heritage and Recreational Enhancement Act) Highlights involving silencers: Just thought I'd pass it along. Cheers.
  8. CountryGent

    If the Hearing Protect Act Passes, what will you do ....

    The title kind of says it. If the Hearing Protection Act passes and silencers are now Title I, so you can buy them with a simple background check, a 4473, and out the door, would your acquisitions be any different? If so, how?
  9. Joe Link

    Gun silencers are hard to buy. Donald Trump Jr. and silencer makers want to change that

    Gun silencers are hard to buy. Donald Trump Jr. and silencer makers want to change that Full Article
  10. 11Charlie

    Marine corp adding silencers

    This makes perfect sense to me. Corps Wants to Put Silencers on a Whole Infantry Battalion | Military.com
  11. CountryGent

    Hearing Protection Act

    The Hearing Protection Act of 2015, while having support from a number of members of congress, had no real chance of becoming law as BHO would have vetoed it if it ever got to his desk. However, there is a new president being sworn in come January and the GOP has majorities in the Senate and...
Back Top