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folding
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil.
Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding begins to occur even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence or primary structure (Anfinsen's dogma).The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded, so that protein dynamics is important. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by incorrect folding of some proteins, because the immune system does not produce antibodies for certain protein structures.Denaturation of proteins is a process of transition from the folded to the unfolded state. It happens in cooking, in burns, in proteinopathies, and in other contexts.
The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete. On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step. Time scales of milliseconds are the norm and the very fastest known protein folding reactions are complete within a few microseconds.
Catch and release. Cool as hell, comfortable and longer LOP than even the minimalist plus sig stock
$175
Will trade for a PMM or OG SIG Kate Moss folding stock with pic hinge
Brandon
9514426918
Really not needing it and it never got used.
I'm gonna let it go back to the wild.
$130
Or trades.
Interested in more p320 stuff. 21/17 round mags are top priority.
30 round metal ar mags. I need some 10 round 458 mags so looking for a stack of cheap mags.
Ar stuffs.
Buis, cheap...
Looking for a pic mount folding brace. Would prefer the SB 1913 brace that is pictured but
Open to all styles.
Let me know what you have!
I have cash, ammo, and an assortment of firearm related goodies to trade.
Pretty much new in box. Purchased this a few months back but went with something else and never even installed it. Comes with T27 bit.
Willing to ship or meet in Albany. Cash, Venmo, or PayPal F&F. Not looking for trades at the moment.
Thinning out the collection,
Have a folding Vepr 12, 12 gauge shotgun that have shot just a handful of times, original box, Has an ALG trigger, original 5 round mag and 3 additional SGM mags.
Been sitting in the safe and less than 100 shells through it.
$1,100 not interested in trades...
This has been a great setup. But, Bidenomics have hit. So, here it is. I ran this on an 80% lower / converted, with the parts included. Will ship for $10
16" sig sauer Legacy (gen1 of the Virtus 1lb lighter different handgaurds)
Upper has between 1k - 1,500 rounds fired. Overall conditions...
Basically new ak shot under 60 rounds comes with 4 magpul mags and 4 psa ak 103 mags also comes with 150 rounds of tula and golden tiger mix of fmj and 20 rounds of soft point asking 1,000 firm not looking for trades
I have 3 20rd mags for it, I shot 60rds thru it so far.
I’ll take $2,200 cash , optic not included unless buyer wants to pay $500 on top of the rifle.
Here’s the description on DSA site.
The DS Arms SA58 I Series of rifles is an improved and enhanced development of the tried & true and very...
Hello All,
Up for sale today is a really nice AMD-65 classic comblock Hungarian AK. Older kit build on Cleveland ITM Arms Co. receiver using a Hungarian military barrel, done right. The 14" barrel has a pinned and welded 2" extension and improved flash hider to bring the full barrel length to a...
Hello I have several Kershaw knives I am taking offers on. These are all factory seconds purchased at the warehouse holiday sale last December. They all are in like new condition and fully function as they should. Models are listed below. If you see something you like let me know which one and...
Excellent condition Gen 3M. I installed it on an AR9 about a year ago and only shot it for a couple hundred rounds and it’s been sitting in the safe ever since. Don’t have much use for it. Located in Tualatin near Cabelas.
This is the top of the line model with all the features (folding + adjustable) Was mounted only, never short through, in like new/excellent condition. Fits any picatinny and can to easily change from left to right folding. 6 position adjustable length of pull, 5 position butt stock and 4...
This is a 4 pack of Alera padded folding chairs, they are unopened and still sealed in the box they came in. They sell for $100ish brand new, selling for $60
SB Tactical MP5 brace.
In excellent condition.
$150 or possible trade.
Interested in high quality bipods (Atlas, MDT, etc.)
Ammo 5.56, 9mm, .308, 6.5 Creedmor, Match Grade .22 LR.
KAC Folding Micro Rear Sight, 200-600 Meter Adjustable
Just received it today and decided to go with another set-up.
I take PayPal friends and family/Venmo
Shipping OK, S/H $4.99
No trade requests please.
No separate part sales please
No face-to-face sales requests please