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Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil.
Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding begins to occur even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence or primary structure (Anfinsen's dogma).The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded, so that protein dynamics is important. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by incorrect folding of some proteins, because the immune system does not produce antibodies for certain protein structures.Denaturation of proteins is a process of transition from the folded to the unfolded state. It happens in cooking, in burns, in proteinopathies, and in other contexts.
The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete. On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step. Time scales of milliseconds are the norm and the very fastest known protein folding reactions are complete within a few microseconds.
Installed it once and took it off my ak. Its collecting dust so maybe somebody else would enjoy it.
It folds, its basically new, i still have the box.
I would prefer face to face in gresham or sandy, but if you want it bad enough you pay shipping and i will ship it out friday.
If you dont...
Bonesteel Arms / CNC Warrior folding AK pistol brace, for Romanian draco, folds to the left. Comes with mounting hardware. You need to drill a hole in the back of the receiver, Bonesteel has videos showing you how to do that.
Full Conceal Factory Glock 43 (9mm) for sale. 50 rounds tested through it - I have 2 of them, keeping 1.
This firearm is RARE and SOLD OUT everywhere. Comes with one magazine, factory Glock box.
CASH ONLY, NO TRADES - buyer pays for FFL transfer in Portland, Willsonville, or Salem Metro...
Looking for Emerson folding Karambit, regular, super, or newer combat model. No beaters please.
Let me know what you’ve got.
in Vancouver WA, will cover USPS small box flat rate and pay with USPS MO unless cash locally.
Complete Ready-to-shoot, AR15 with Red dot, MBUS back up sights, Streamlight Weapon light with pressure pad installed MOE EPT Lower build and SBA4 stock.
Barrel: 10.5" 4150V Chrome Moly vanadium steel, phosphate coated and chambered in 5.56 NATO with a 1 in 7" twist. Carbine length gas barrel...
Stainless/Black Butler Creek folding stock for Ruger 10/22. Very good used condition. Locks up/down nice and tight. Only fits the standard tapered 10/22 barrel, but I'd imagine you could modify it for a bull barrel, or cut it down for a short Charger barrel. Sale on eBay over the past...
WASR Romanian Cugir ak47 with Romanian military folding wire stock.
Very very few rounds fired.
I’d like to trade this for your old Winchester rifle (lever or treating rimfire/22) or model 42 410ga shotgun.
Selling a like new Law Tactical Gen 3-M AR Folding Stock Adapter. I installed it on my rifle and put maybe 25 rounds through it. Great piece of equipment but just going a different direction. Only thing missing is the original box and installation instructions (but you can find them online or...
My apologies for posting this stuff a few times, and in a few different configurations. I hate polluting the classifieds with things again, and again, but promise that this is a last attempt to find this lovely kit a new home. It's a stainless Ruger 10/22 with a Butler Creek...
Just testing the waters. I have very specific trade interests and am looking for a Browing B-92 in 44 magnum, two stainless Ruger Vaqueros, or a nicer AK variant. Trade only at this time.
182 series mini 14 in aftermarket samson a-team folder. Stainless, as God intended the mini 14 to be.
For Sale is an unused and hard to find Hogue EX-02 3.75in Sig Folder Spear Point Blade Flipper, Flat Dark Earth Finish, G10 Scales are Green (Scorpion), Blade Length 3.75", Closed Length is 5.13" and overall Length is 8.75". Hogue crafted these pocket knives from 154CM stainless steel for...