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folding
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil.
Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding begins to occur even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence or primary structure (Anfinsen's dogma).The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded, so that protein dynamics is important. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by incorrect folding of some proteins, because the immune system does not produce antibodies for certain protein structures.Denaturation of proteins is a process of transition from the folded to the unfolded state. It happens in cooking, in burns, in proteinopathies, and in other contexts.
The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete. On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step. Time scales of milliseconds are the norm and the very fastest known protein folding reactions are complete within a few microseconds.
Bought a few years ago, but I only fired this on two occasions, seems fairly accurate for a 2" revolver.
Original box, both cylinders, both original grip and folding grip.
☆☆ Would trade for a mid to full sized double action 22lr revolver, TX 22, or keltec p32 compact carry gun, i know there...
I bought this new from Atlantic 2 years ago and wasn’t paying attention, as it doesn’t fit my MP5K. This will fit MP5 / HK33 (and clones) with a single pin retention at the rear of the receiver. Never been used or installed.
https://atlanticfirearms.com/mp5-hk33-folding-stock
$100 plus $15...
Vintage Ruger folding stock.
Former LE use; metal frame works well, the wood shows use.
Specifications are in the photos, Ati sez their copy of this fits 181xxx & up Ruger production units.
$325
Cash, no trades
In Portland & Oregon City areas, Clackamas county & Columbia Gorge.
Thanks,
John
Bought back in 2020. Mainly used to open packages. Was not used in any extreme way. Blade edge isn't razor sharp, but it's sharp enough.
Locks up fine. Pocket clip works fine. All around good knife that works.
$15 shipped anywhere in the continental United States.
PayPal, Zelle, Venmo...
PSA AK-104 with a 12.5 barrel and folding triangle brace. Has the PSA ALG AKT enhanced trigger. Comes with (9) 30 round PMAGS and (1) PSA 30 round magazine. 150 rounds through it. I’m the original owner. Making room in the safe so it’s up for grabs. I’d like to get 800 for it. No trades. Meet at...
Odin GL Tactical Flashlight Picatinny Black - Both brand new, one is open just to look at it but put back right away. Retail is $210 but selling for $90 each or $150 bundle. Willing to ship
In like new condition. Recently removed from my factory SP5K after the SBR paperwork came through. This is the brace only. Does not include the B&T or HK Parts Folding Stock Adapter for the MP5/SP5/SP5k and UMP, which you’ll need. Links to some MP5/SP5 adapters are below.
B&T...
I have a brand new set of AUTHENTIC Troy Front & Rear FDE Folding Battle Sights that have been collecting dust in my parts bin. There are hands-down my favorite backup iron sights, and I'm running them on several of my rifles. I just have more sets than I need!
If you've never used Troy's...
Very good condition Remington 870 / 870 Police Magnum factory top folding stock. These are rare and haven't been manufactured in 20 or 30 years. This is a very compact setup and the stock lockup is tighter than any aftermarket folding options. The buttpad was modified by a machine shop to be...
Lighter bolt extension. Was apart of the ar folder bandwagon and never used it. It was mounted and never shot.
Put it on and took it off. Package is gathering dust.
140$ Cash or trades.
Please not this sale is only for the barrel and front sight. The receiver assembly and bolt carrier group and side sling, handguards and delta ring assembly available at extra cost.
ARMS #41 SILHOUETTE™ Front Folding Sight Taper Pinned by TNTE to a Stag ARMS chrome lined 1/9 Twist Barrel. The...
Lowest price ever by a long shot per the price history. I personally prefer the electronic kind but these are a good backup.
Merry Christmas everyone!
https://www.preppingdeals.net/deals/amazon-walkers-pro-low-profile-folding-earmuffs
Looking specifically for the Micro sights as I'm trying to witness through a skeletonized Scalarworks mount. These specific micro sights are the only ones I've researched that are short enough to potentially pull that off. ONLY looking to meet in person because I will not purchase IF the sights...
Palmetto State Armory
AK-103 GF3
7.62x39mm
Low round count (<60 rounds). No mags included.
$650 shipped. Out of state sale only. Buyer’s responsibility to make sure they are in compliance with their state/local laws.