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It is a fact, about five percent of humans and an unknown percentage of dogs are simply immune to pepper spray. I personally had such a a dog that was completely immune to the effects. I have no idea if any creature has immunity to CS/CX gas spray, but I try to carry a defense spray that combines BOTH pepper and CS/CX, in case the pepper fails.
My main point is to carry backup to your defense spray in case it is not effective or if the wind is against you. And I would not even consider a knife unless the attacking dog has already got a "death-bite" on your pet or yourself. The thing is, dogs in combat are just incredibly fast and can chomp down on your knife hand well before you can use it, and then shake you to death. And I would not want to offer it my other hand as a "sacrifice" to keep the knife hand free. You need to deal with the beast at a distance and not let it bite you. When I walked my dobie I usually carried a gun, spray, and a heavy walking stick. The latter was very useful for poking away silly challenging dogs........................elsullo
My main point is to carry backup to your defense spray in case it is not effective or if the wind is against you. And I would not even consider a knife unless the attacking dog has already got a "death-bite" on your pet or yourself. The thing is, dogs in combat are just incredibly fast and can chomp down on your knife hand well before you can use it, and then shake you to death. And I would not want to offer it my other hand as a "sacrifice" to keep the knife hand free. You need to deal with the beast at a distance and not let it bite you. When I walked my dobie I usually carried a gun, spray, and a heavy walking stick. The latter was very useful for poking away silly challenging dogs........................elsullo