I carry with a round in the chamber, but I am VERY picky about which handguns I will use. For instance, I will not carry almost all striker fired handguns since most of them have the "safety trigger" which does nothing to make the gun safer, and worse yet, gives you a false sense of security. IMHO, all GLOCKS are unsafe to carry with a round in the chamber, their triggers are light and they do not even have a safety. The best gun to carry with a round in the chamber is a hammered DA/SA with a long first shot trigger throw and a safety that will NOT easily be disengaged. The Ruger P series is excellent, and if they were lighter and single stack, they would be my choice for everyday carry. Currently, the only handgun which meets all my requirements for everyday carry with a round in the chamber is my little FIRST GENERATION Ruger LCP. It has a very long, stiff, trigger throw, and no useless "trigger safety" like the LCP Second Generation, which I would not own. I want a small, single stack 9MM with a hammered DA/SA and a GOOD safety, but I have not been able to find one. If anyone knows of such gun, please let me know.