The elevation change between my rifle range in the Portland area and where I hunt over east makes a noticeable POI shift. I always go to elk camp 2-3 days early to cut firewood and dial-in my rifle (about 20 miles from camp).
Ballistics data don't bear that out as far as I can tell. With a 30'06 and a 168gr bullet, there is one inch less drop at 300yds.