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folding
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil.
Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding begins to occur even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence or primary structure (Anfinsen's dogma).The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded, so that protein dynamics is important. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by incorrect folding of some proteins, because the immune system does not produce antibodies for certain protein structures.Denaturation of proteins is a process of transition from the folded to the unfolded state. It happens in cooking, in burns, in proteinopathies, and in other contexts.
The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete. On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step. Time scales of milliseconds are the norm and the very fastest known protein folding reactions are complete within a few microseconds.
I have nice Polish Beryl side folding stock for sale. These are getting hard to find and this one locks up as new! These fit on all European AK's with the standard 1.0 rear trunion. I think these are the most solid folders on the market. Folds to the right side. Asking $250.00 OBO, buyer pays...
Went a different route with my CZ Scorpion so I’m selling as an used but excellent condition lot:
(1) Strike Industries QD Stock Adapter for the CZ Scorpion (new-unused)
(1) Strike Industries Grooved Selector Switch set (new-unused)
(1) Used 1/2”x28x5” KAK Flash Can with fresh new crush washer...
Can anyone identify this proof stamp. I bought this lockblade from an Italian knife shop while on deployment back in 90-91 time frame. The flush rectangular button at the butt of the handle is the blade lock release. Would also like to know the handle material also.
Just what the title says
JMac Customs Tanodize arm bar AB-8R
Sig 1913 Folding Mechanism
JMac brace adapter
Gearhead Works Tailhook Mod1
None of these have ever been out of the house. Mounted the arm bar briefly and then went a different direction.
New, this setup would be $415 before shipping...
Used for about a year. Still functions 100%, and in good condition.
I need to shrink down the overall length on a pistol. I still have the packaging and everything it came with.
Sylvan Arms Folding Stock/Brace Adapter Brand new in packaging
Cash (+ shipping, or meet north of Seattle area)
PM me if you want to see my trade list. Thanks!
B&T GHM9 with a Gearhead works tailhook on a factory folding arm. Used but in great shape, I think I only have about 200 rounds through it. Full ambi controls, has factory barrel with both 3-lug and 1/2x28 threads. Comes as new in factory case with sling, etc.
Not interested in any trades. I...
B&T APC9 with SB Tactical folding brace. Used but in great shape, I probably only have about 200 rounds through it. Has factory 3-lug on barrel, full ambi controls. Comes as new, with factory case, sling, etc.
Not interested in any trades. I can deliver to your FFL in the puget sound area or...
Scrapped my AK build project so I’m selling a few parts at a big loss.
unused JMAC modular rear trunnion with folding mech and skeletonized tube for AR type buttstocks.
all 3 pieces delivered for $225
Wood Sks side folding stock fixed position with allen screw! nice condition with epoxied inletting fits really snug on chinese sks action. Comes with bolt for pistol grip can be converted back to a folder by removing the screw and installing a spring!
Had this on my ak for a couple weeks but decided I liked the wood better. It's in great shape, never been out the house with it. Solid quality construction. $150 no shipping no trades. Located in Vancouver.
Tapco Galil Style Handguard and Folding Stock
Stock does come with mounting screws.
$15 Cash
No shipping.
Prefer to meet up at HWY 26 Sportsman's Warehouse or Tanasbourne area.
I’m trying to recoup some cash to help fix my transmission.
#1 on the list is a Tikka T3XTACA1 in 6.5 creedmore with a 24” barrel. Comes with 3 10rd mags and box of goodies it came in. Has a adjustable trigger and is set at 2 1/2 pounds. I have shot some of the best groups with this rifle. The...
I'm selling a Sig MCX style folding brace. This is the more expensive, aluminum model (FS1913A). Sold the gun it was on. Excellent condition. No scratches, etc.
FIT: Platforms with M1913 interface at rear of receiver (SIG MPX, SIG MCX, SIG Rattler, Rock River LAR-PDS, etc.)
WIDTH [MAX]:1.2"...
Anderson lower with PSA parts, cal. 5.56, 10 1/2" barrel, about 200 rounds thru it. $550 OBO in Vancouver. Can meet at Tropic pawn or will ship to your FFL for extra $.
email is the best way to contact me. natrainer at aol. com
Getting out of the Creedmoor game.
Rifle w/tons of components and loaded factory ammo for sale. Tikka T3 action w/proof research CF barrel. XLR Element 3.0 chassis, KRG Tikka 2 stage trigger. Rifle easily shoots sub moa. Won't come with the brake that's on it, it goes with my can. Less than 400...
Need to raise some quick cash! $250 FTF Thursday or Friday in NW Portland!
Looking like I am going to keep my Mini and put the synthetic stock back on it.
The Samson stock is in excellent condition, they used a really nice piece of wood on this one! I will take pictures tonight.
Price is $325...