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folding
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil.
Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding begins to occur even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence or primary structure (Anfinsen's dogma).The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded, so that protein dynamics is important. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by incorrect folding of some proteins, because the immune system does not produce antibodies for certain protein structures.Denaturation of proteins is a process of transition from the folded to the unfolded state. It happens in cooking, in burns, in proteinopathies, and in other contexts.
The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete. On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step. Time scales of milliseconds are the norm and the very fastest known protein folding reactions are complete within a few microseconds.
Hola all,
I have a set of BUIS that I no longer need (FDE Troy 45 Degree Offset Folding Front & Dioptic Rear Iron Sights). I haven't used them.
$140 (retail for about $200-ish)
I bought this for my brother but he said he's not into this kind of device. New and unused for AR-15. Perfect and ready for gift wrapping.
I'm in Seattle near Boeing Field.
Up for sale is a SB tactical folding brace with the stribog adapter. The adapter can be removed and swapped out for other adapters like for B&T or for mp5 models.
100 dollars or 110 shipped
Another that i am selling for my buddy developing Alzheimer's. Nice stainless Ruger Mini 14 with folding Choate stock, sling, 4 mags, carry case, and 200rds of ammo if sold local. Total price $900 and i can meet within 60 miles or so of Roseburg for gas money. I have 8 ads up for him and would...
Used LAW Tactical AR-15/M16 GEN 3-M Folding Stock Adapter
Link to product page: Here
Going rate on Primary Arms and Brownells is $249.99 - Sale price $190
FTF between Marysville and Bellevue - Shipping via USPS on your dime.
Kalashnikov USA KR-103, Non-Side Folding
Never got around to shoot this. Purchased in 2021. Comes with OEM KUSA Hard case, Manuals and one 30rd KCI Magazine.
$1000
Cash Only.
No Trades, No Shipping
Will cover Transfer Fees if done at my preferred FFL in Beaverton.
Kalashnikov USA KR-103, Non-Side Folding
Never got around to shoot this. Purchased in 2021. Comes with OEM KUSA Hard case, Manuals and one KCI Magazine.
$975
Cash Only.
No Trades, No Shipping
Prefer to meet in Tanasbourne/185th Sportsman's warehouse area.
I’ve got a like new A3 Tactical folding brace for the B&T APC. This fits the APC9 and APC45. It can be configured to fold to the left or right. Great design, but I’ve decided to SBR mine, so I no longer desire a brace. More pictures available upon request.
Includes original box/contents...
Great shape. Stock has a crack (doesn’t effect anything) and I can install a wood or synthetic Instead If you’d like. Will come with 1 -25rd mag.
300$ + 25$ transfer at elite buyers in west Salem.
Folding single barrel shotgun. Not much else to say.
Unfired FabArms shotgun. Great for truck gun or camping gun.
Open to trades. I am looking for a 458 SOCOM ammo I am willing to add cash to even a trade
I'm not finding info anywhere. This is with no brace, just a standard AR pistol extension and sponge cover. Do any of you guys have a clue or could you point me to a legal source? Thank you.
140 for the set 75 for each sight post, open to the right trade message me. the front post is painted neon green on only the actual post on the side facing the shooter