Well if your looking to save set-up time and use HS-6 for your 40 and 38spl, it did not work for me. I tested 125gr FMJs over 6.5-7.3grs of HS-6 in the SP101. Lots of unburned powder, erratic velocity and random muzzle flash. I have heard that it works for +P loads but i don't want to go that route. I guess i'll stick with Unique and Trail Boss for now. HS-6 works really well with 180gr and the 40s&w and flows like water through the measure. I hope a can save someone some trouble and components. Stay safe and shoot often!