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Myelin is a lipid-rich (fatty) substance formed in the central nervous system (CNS) by glial cells called oligodendrocytes, and in the peripheral nervous system (PNS) by Schwann cells. Myelin insulates nerve cell axons to increase the speed at which information (encoded as an electrical signal) travels from one nerve cell body to another (as in the CNS) or, for example, from a nerve cell body to a muscle (as in the PNS). The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Rather, each myelin sheath insulates the axon over a single section and, in general, each axon comprises multiple long myelinated sections separated from each other by short gaps. Each myelin sheath is formed by the concentric wrapping of an oligodendrocyte or Schwann cell process around the axon.
More precisely, myelin speeds the transmission of electrical impulses called action potentials along myelinated axons by insulating the axon and reducing axonal membrane capacitance. This results in saltatory conduction whereby the action potential “jumps” from one node of Ranvier, over a long myelinated stretch of the axon called the internode, before 'recharging' at the next node of Ranvier, and so on, until it reaches the axon terminal. Nodes of Ranvier are the short (~1 micron) unmyelinated regions of the axon between adjacent long (~0.2 mm - >1 mm) myelinated internodes. Once it reaches the axon terminal, this electrical signal provokes the release of a chemical message or neurotransmitter that binds to receptors on the adjacent post-synaptic cell (e.g. nerve cell in the CNS or muscle cell in the PNS) at specialised regions called synapses.
This “insulating” role for myelin is essential for normal motor function (i.e. movement such as walking), sensory function (e.g. hearing, seeing or feeling the sensation of pain) and cognition (e.g. acquiring and recalling knowledge), as demonstrated by the consequences of disorders that affect it, such as the genetically determined leukodystrophies; the acquired inflammatory demyelinating disorder, multiple sclerosis; and the inflammatory demyelinating peripheral neuropathies. Due to its high prevalence, multiple sclerosis, which specifically affects the central nervous system (brain, spinal cord and optic nerve), is the best known disorder of myelin.
Gerber folding Pocket knife Pat. Pending Portland, Ore. No model marking has a S stamped above the Gerber. has a few light scratches. Could be Easly restored to mint condition. It comes with Gerber sheath and steel sharpener $250 Available in SE Portland. Lonny
Like new Toor Anaconda. Black in color. Never been used to cut. Not sure if I want to sell but I am trying to fund another project. Box, cloth, card, sheath, and unopened frog lube included. The multiclip will be removed and I will include an inside the waistband clip.
Knife is in great condition comes with leather belt sheath. Anza knives are American made in San Diego. This one was made from an old file. Edge is screaming sharp and handle is very ergonomic.
Trade for other cool knives
Ka-Bar Becker Bk2. Stripped finish. Standard hardware replaced with stainless bolts amd brass nuts. Sagewood Randall sheath. Silverstag fire steel. The knife and sheath have only been used a couple times. The fire steel has never been used.
The sheath alone will run you $120 from...
Like the title says...
I can't find anyone on the usual search engines, so does anyone have somebody good?
I'm on a budget, but it doesn't have to be cheap either.
It's for that Blackjack I bought and I'm having zero luck.
Thanks for your help.
Bought this last year and carried it twice but it just isn't my style. I really appreciate the concept and wanted to like it but for whatever reason I just am not vibing with this knife. Never used, or removed from sheath other than to check after receiving from factory.
Sheath has belt clip...