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If it's blasting ammo then don't concern yourself but if you want true accuracy then stick to the load you built. The answer is yes there is a difference in primers.
If I am loading bulk with forgivable tolerances, I don't care.
If I'm going nuts chasing small groups. I care. Usually make notes of what works best and stick to that for repeatability.
Last batch of 5k 223/556 bulk, I used wolf small rifle magnums. Zero noticeable difference in going bang in my ARs. Groups in slow mode (aka actually trying) are 1-1.5" at their smallest. Chronograph spread was sub 100fps. Not the greatest, but I don't measure meticulously for each round when loading my bulk stuff that I shoot mostly for practice. I just charge cases via a powder flow. I'm not at the top end either so I'm not worried about pressure problems.
Few months ago I made a comparison between CCI, Federal, Win and Rem LR primers (using the exact same powder charge, same brass cases and same bullets) and I absolutely saw NO difference. However, it is possible that for some reloads primers can make significant difference, but I personally never experienced it. I only reload large rifle ammo.
My understanding is that in rifle/pistol reloading primer differences are negligible, you can even swap rifle and pistol primers in some instances. However with shotshell loading a primer swap can cause significant and dangerous pressure spikes.
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