p225a1

TRNA:m4X modification enzyme (EC 2.1.1.225, TRM13, Trm13p, tRNA:Xm4 modification enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction
(1) S-adenosyl-L-methionine + cytidine4 in tRNAPro



⇌


{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro
(2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC)



⇌


{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC)
(3) S-adenosyl-L-methionine + adenosine4 in tRNAHis



⇌


{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis
The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.

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