How do you select which bullet weight to use for hunting?

I'm buying components to handload a new 280AI for elk hunting. Ive narrowed down to either a Barnes TTSX or a Hammer Hunter. I'm looking thru the various weights they offer and kinda stalled out on picking the heaviest or choosing a lighter weight. I'm playing around in a ballistic calculator but don't really have a metric to judge a starting velocity for each weight.
Barnes TTSX: 140, 150gr, Hammer Hunters: 146, 155, 169, 177gr.
The 150 TTSX would be my choice if your rifle like it.

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