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What is your cartridge?If you hit vitals it will do the job. I have been hunting open country mulies for 30 years and have only had to shoot longer than 300 a handful of times. Best tool is a good set of binocs and patience to make sure and see them before they see you. Even if they spot you first as long as they are a ways off, you can turn on your heels and let them watch you walk directly away from them until you can find a fold of land to disappear behind. Then hopefully you can plan a sneak downwind from an angle they are not expecting. I can't tell you how many mule deer have fallen for this tactic I learned many years back. Many of these shots have been up close and personal as well. Good luck
What do you think of this 120 gr. Speer Boat Tail?
BC is .480. I don't think that's too shabby, but you seem to have quite a bit of experience with this caliber.
So if you want to use the heavier bullets, like that Speer, you really need a little tighter twist (1:8, 1:9, etc.), right?