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Pennsylvania Route 10 (PA 10) is a 44.04-mile-long (70.88 km) state route in southeastern Pennsylvania. Its southern terminus is at PA 472 in Oxford. Its northern terminus is at U.S. Route 222 Business (US 222 Bus.) in Reading. PA 10 is mostly a two-lane undivided road that serves Chester, Lancaster, and Berks counties. The route begins in Oxford and passes through rural areas of western Chester County, serving Cochranville, Parkesburg, Compass, and Honey Brook. The route passes through a small corner of eastern Lancaster County before it enters Berks County and reaches Morgantown, where it has interchanges with Interstate 176 (I-176) and the Pennsylvania Turnpike (I-76). Between Morgantown and Reading, PA 10 parallels I-176.
The road between Oxford and Reading was originally designated as Legislative Route 274 in 1911. In 1927, this road became a portion of PA 42, which continued north from Reading to northern Pennsylvania. The PA 42 designation was replaced with US 122 in 1935; US 122 ran between Oxford and Reading and continued north to Northumberland. In the 1950s, PA 10 replaced the US 122 designation between US 1/PA 472 in Oxford and PA 23 in Morgantown. US 122 was decommissioned in 1963 and PA 10 was extended north along the former alignment between Morgantown and US 222 (now US 222 Bus.) in Reading.

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