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Join the #1 community for gun owners of the Northwest
We believe the 2nd Amendment is best defended through grass-roots organization, education, and advocacy centered around individual gun owners. It is our mission to encourage, organize, and support these efforts throughout Oregon, Washington, Idaho, Montana, and Wyoming.
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ONX-0801 (BGC 945) is an experimental drug that has been developed to target ovarian cancer. It is an alpha-folate receptor mediated thymidylate synthase inhibitor.
ONX-0801 was originally developed by BTG and the Institute of Cancer Research in the UK, and subsequently licensed to Onyx Pharmaceuticals for clinical development. It is designed to selectively target tumour tissues of certain kinds of cancer. It is poorly absorbed into most cells, but is actively transported by an enzyme α-folate receptor (FRα), which is usually only expressed at low levels in the apical membrane of some specialised tissues, but is expressed at much higher levels in some subtypes of ovarian cancer. This causes the drug to accumulate selectively in tumour tissues, while healthy tissues are only exposed to a much lower concentration.
In 2017, it received press coverage following the successful completion of a Phase I clinical trial.
Got this from another member here but I am in need of some cash. This thing is basically brand new. It also comes with the all the Oregon OnX hunting maps (119 dollar value). I am willing to meet anywhere in central Oregon or the east side of Portland. I can ship if need be. I might be willing...
Has anybody had experience with the app here? Is it worth using the GPS with the OnX chip or does the app suffice? Can the app be used reliably when no cell phone coverage is present? What are the major drawbacks to each system? Any input or suggestions would be greatly appreciated!