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The .45-75 Winchester Centennial is a centerfire rifle cartridge developed in 1876 for the newly designed Winchester Model 1876 Centennial lever-action rifle. Winchester Repeating Arms Company introduced the rifle and cartridge at the United States Centennial Exposition. The Model 1876 rifle used an enlarged version of the famous Winchester Model 1873 action to offer a lever-action repeating rifle using cartridges suitable for big-game hunting. The cartridge and rifle enjoyed brief popularity with Gilded Age American hunters including Theodore Roosevelt, and was issued to the Canadian North-West Mounted Police and to Texas Rangers.

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