It's always good to think about your neighbors and over penetration. A single shot 410 makes a nice club after you miss with that first shot though. If you want to go 410, get a Taurus Judge. Then you get 5 rounds of 410 to take care of business (or 45 Long Colt). If you miss with five rounds, then you could always go NY style and just stab the bad guy in the neck with a fork.
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