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spot
SpoT is a bacterial protein that hydrolizes alarmones, (p)ppGpp, in the bacterial stringent response. Its hydrolase activity is Mn2+-dependent with a conserved His-Asp (HD) motif. In E. coli, SpoT protein consists of 693 amino acids. SpoT belongs to the RSH protein family.
It is bifunctional, has both hydrolase and synthase activities. When relA is deleted, E. coli still can produce (p)ppGpp by SpoT.
SpoT can sense many sources of nutrient stress other than amino acid starvation and to respond by limiting hydrolase. The acyl carrier protein (ACP) binds to the TGS domain of SpoT; this binding is probably influenced by the ratio of unacylated ACP to acylated ACP in the cell. Fatty acid starvation leads to a shift in the balance of the two SpoT activities in favor of synthesis. Phosphate starvation is sensed by SpoT hydrolase to elevate (p)ppGpp, which induces IraP, a RssB antiadaptor that antagonizes RssB activation of RpoS turnover, thereby inducing RpoS.
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It is bifunctional, has both hydrolase and synthase activities. When relA is deleted, E. coli still can produce (p)ppGpp by SpoT.
SpoT can sense many sources of nutrient stress other than amino acid starvation and to respond by limiting hydrolase. The acyl carrier protein (ACP) binds to the TGS domain of SpoT; this binding is probably influenced by the ratio of unacylated ACP to acylated ACP in the cell. Fatty acid starvation leads to a shift in the balance of the two SpoT activities in favor of synthesis. Phosphate starvation is sensed by SpoT hydrolase to elevate (p)ppGpp, which induces IraP, a RssB antiadaptor that antagonizes RssB activation of RpoS turnover, thereby inducing RpoS.
View More On Wikipedia.org
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90% junk silver half dollars below spot
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- For Sale
- $70
- Canby
- Oregon
I have the following 90% junk silver half dollars at $3.85 below spot silver. $40 face value consisting of the coins pictured below. Walking Liberty, Franklin (brilliant uncirculated and circulated) and 1 - 1964 Kennedy. Closing spot on Friday was $103.29 according to Harry's Coin Shop. Link...- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
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- Tags
- junk silver spot
- Replies: 1
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.999 pure Silver Ounce Coins spot
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- For Sale
- $95
- Oregon City
- Oregon
(4) .999 pure silver ounce rounds this weekend only. 380 for all four. I might be persuaded to sell more if interested. -
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Couple ounces of silver bullion for spot
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- For Sale
- Beaverton
- Oregon
I have 4 troy ounces of silver bullion .999 fine I want to sell for spot.- Classified Ad
- Non-Firearm Item Classifieds
- BZKurd
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- Tags
- silver bullion spot
- Replies: 4
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Silver bullion for sale at SPOT
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- For Sale
- Eugene
- Oregon
Have mix of silver rounds (1oz) & bars (3oz, 10oz) available sale at current spot (per APMEX). Up to 100oz available. No trades. Meet between Eugene and Albany areas. Message me directly if interested.- Classified Ad
- Non-Firearm Item Classifieds
- Flounder
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- Tags
- for sale silver bullion spot
- Replies: 5
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Silver bullion rounds and coins $1 UNDER spot.
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- For Sale
- $1
- Salem
- Oregon
Selling some silver to help with some vet bills. Everything is either 999 or 999.9 fine. Some very nice rounds and coins. .5, 1, 1.25 and 1.5 oz. Coins available. Pandas are spot unless you buy all 3 then $1 under. Everything else even premium coins are Selling for $1 UNDER current spot price...- Classified Ad
- Non-Firearm Item Classifieds
- DennisS
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- Tags
- coins silver bullion spot
- Replies: 4
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Morgan and Peace Silver Dollars @ Spot
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- For Sale
- $40
- Canby
- Oregon
Selling Morgan and Peace Silver Dollars @ Spot Silver. Assortment of Pre 1921 Morgan, 1921 Morgan and Peace Silver Dollars. 20 coins available. I'd like to keep this at a minimum of 5 coins. Current spot at AJPM.COM is $51.39. $51.39 × .7734 = $39.75 silver content and value. $40 each...- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
- Replies: 1
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1878-1904 Morgan Silver Dollars @ Silver Spot
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- For Sale
- $42
- Canby
- Oregon
1878 - 1904 Morgan Silver Dollars @ Silver Spot 44 coins available Selling these in sets, as pictured. 2 of the 3 sets of coins are different dates and mint marks. 20 coins in a set, 14 coins in a set, 10 coins in a set. Take your pick. Please identify which set you would like in your...- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
- Replies: 1
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1922 Peace Silver Dollars @ Silver spot
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- For Sale
- $39
- Canby
- Oregon
1922 Peace Silver Dollars @ Silver spot Almost Uncirculated- AU condition coins 15 available Silver spot at KITCO.COM closed Friday at $50.01 Peace Silver Dollars contain .7734 Troy ounce of silver. $50.01×.7734=$38.68. Cash only transaction, no trades at all.- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
- Replies: 1
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Peace Silver Dollar Collection @Silver spot
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- For Sale
- $39
- Canby
- Oregon
I'm selling an almost complete Peace Silver Dollar collection. There are 24 coins to a complete collection. This set consist of 22 coins and DOES NOT have the 1921 or 1928, the 2 most expensive coins to purchase. I will not break up this set. Silver spot at KITCO.COM closed Friday at $50.01...- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
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- Tags
- dollar peace silver dollar spot
- Replies: 1
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Peace Silver Dollars @ Silver spot
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- For Sale
- $39
- Canby
- Oregon
Peace Silver Dollars @ Silver spot 6 coins available as a set of different dates and mint marks. I will not break up this set. 12 coins available as a set of different dates and mint marks. I will not break up this set. Silver spot at KITCO.COM closed Friday at $50.01 Peace Silver Dollars...- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
- Replies: 1
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1921 Morgan Silver Dollars @ Silver Spot
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- For Sale
- $36
- Canby
- Oregon
1921 Morgan Silver Dollars @ Silver Spot. No junkers! Nice coins in XF/AU condition. At this present moment (9/30/25), Silver spot at AJPM.COM is $46.70 Each Silver dollar contains .7734 Troy ounce of silver. $46.70 ×.7734=$36.12 dated 9/30/25 Cash only transaction, no trades at all...- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
- Replies: 2
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Junk silver, Morgan and Peace Dollars, Below Spot
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- For Sale
- For Trade
- Lake Stevens
- Washington
Raising some cash for other purposes. Converting some of my silver into gold as well. (As such more than open to a trade for fractional gold coins or bars.) I have offered stuff before but not at the prices I am going to offer this time around! Spot closed at $38.10 asking (Depends a bit on...- Classified Ad
- Non-Firearm Item Classifieds
- coltemp
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- Tags
- junk silver morgan peace spot
- Replies: 0
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GPS SATELLITE PERSONAL TRACKER MESSENGER
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- For Sale
- $20
- Vancouver
- Washington
( SPOT ) SATELLITE PERSONAL TRACKER TRAVEL SAFELY ANYWHERE IN THE WORLD AND LIVE TO TELL ABOUT IT NEW IN THE BOX UNUSED GPS MESSENGER Product Information Travel safely anywhere in the world, with the SPOT Personal Tracker. This satellite GPS messenger selects your GPS coordinates, to zero...- Classified Ad
- Non-Firearm Item Classifieds
- fredball
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- Tags
- gps satellite spot tracker
- Replies: 0
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APMEX 1 ounce Silver bars
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- For Sale
- $34
- Canby
- Oregon
APMEX 1 ounce Silver bars. CASH ONLY transaction, price is firm. No trades or price breaks. FTF in Oregon City, Wilsonville, Woodburn or Canby.- Classified Ad
- Non-Firearm Item Classifieds
- Colt Carbine
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- Tags
- ounce silver bars spot
- Replies: 0
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Sliver bars beneath spot price
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- For Sale
- $120
- Tualatin
- Oregon
4 Apmex ounce silver bars sealed.- Classified Ad
- Non-Firearm Item Classifieds
- Shootingred994
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- Tags
- silver silver bars spot
- Replies: 1
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WTT/WTS: Zoleo S.O.S. & Two Way SMS Global Communicator
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- For Sale
- For Trade
- $125
- Roseburg
- Oregon
Uses Bluetooth to send text messages from your phone from anywhere in the world without needing a cell signal. I didn't need it so it's still sealed in the original packaging. I live in Coos Bay but could potentially meet in Roseburg or up to Eugene for the right trade. TRADE INTERESTS...- Classified Ad
- Non-Firearm Item Classifieds
- Omni
- Replies: 0
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Shooting spot(s) near Wallowa Lake?
Going on a small retreat with the in-laws this summer to Wallowa Lake and was hoping to segue for a little target shooting. The open areas are pretty vast but I don't know the area well and was hoping for a suggestion or two of a 50-100yd spot to shoot with a good berm, etc. As always, I'll...- Discussion Thread
- Outdoor Shooting Areas
- Jcon268
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- Tags
- shooting shooting spot spot
- Replies: 0
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Outdoor Spot around Florence Oregon
Hey all, I just finally moved out of washington county to Florence. Unfortunately that lost me access to the tillamook forest and its lanes, however its for the better for me and my wife. I am going to be a member of the gunclub down here but there are a couple of "restrictions" no steel on...- Discussion Thread
- Outdoor Shooting Areas
- Knebel
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- Tags
- florence oregon outdoor spot
- Replies: 3
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NYC Robbery of Fish Spot in Washington Heights
I hate videos like this but I do believe it's important to view them for lessons learned and to be aware of just how violent the criminal element can be. It's pretty gory at the end so be aware if you don't want to see a lot of blood. It's pretty messed up as the bad guy pops the guy at the...- Discussion Thread
- Defensive Carry & Self Defense
- L84Cabo
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- Tags
- spot
- Replies: 2
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22.56 gram Oregon Placer gold smelted button tested to 22k or (.916) purity from acid test (Below spot price!!!)
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- For Sale
- For Trade
- $1200
- Wilsonville
- Oregon
22.56 grams Oregon Placer gold smelted button tested to 22k or (.916) purity from acid test (Below spot price!!!) Spot price as of today is $1349.16 Will sell for $1200.00 obo smelted down to 4 nuggets equaling 22.45 grams of tested to .916 purity or 22k Gold prices are going up so I'm going to...- Classified Ad
- Non-Firearm Item Classifieds
- jessygirl20150
- Replies: 3
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