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A Panthera hybrid is a crossbreed between any of the four species tiger, lion, jaguar and leopard in captivity.
Most hybrids would not be perpetuated in the wild as males are usually infertile. Mitochondrial genome research revealed that wild hybrids also occurred in ancient times. The mitochondrial genomes of snow leopard and lion was more similar to each other than to other Panthera species, indicating that at some point in their history, the female progeny of male ancestors of modern snow leopards and female ancestors of modern lions interbred with male ancestors of modern snow leopards.

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