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The .458 Lott is a .458 caliber rifle cartridge designed for the purpose of hunting large, thick-skinned dangerous game animals in Africa. It is based on the full length .375 H&H Magnum case blown out and shortened to 2.800 inches (71.1 mm).The .458 Lott was designed in response to perceived inadequacies and problems encountered with the .458 Winchester Magnum. The cartridge provides a distinct step up in performance over the .458 Winchester Magnum. A-Square, Česká Zbrojovka/Brno, Hornady, and Ruger have been instrumental in the cartridge's rise in popularity.

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