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Interstate 22 (I-22) is a 202.5-mile-long (325.9 km) Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway System. Designated in 2012, I-22 follows the route of the older U.S. Route 78 (US 78). The freeway mainly spans rural areas and passes numerous small towns along its route, including Jasper, Winfield, and Hamilton in Alabama; and Fulton, Tupelo, New Albany, and Holly Springs in Mississippi.
I-22 was upgraded to Interstate Highway standards to close a gap in the Interstate Highway System, allowing for more direct connections between cities in the southeast with cities in the central part of the country. I-22 indirectly connects I-240, I-40, I-55, and I-69 in the Memphis metropolitan area via US 78 and I-269 with I-65, I-459, I-20, and I-59 in the Birmingham metro area.

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