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HK 45C?
Own both but I would have to give an edge to the M&P for handling. Because it is slightly lighter, and significantly thinner, it feels better when concealed and also when drawing and operating. It is about .25" longer than the PX4 but you also gain .5" in barrel length. I've always found length more easily to deal with than overall thickness for concealment. If you like the feel of the PX4 and are already leaning towards it - I would buy it and not look back. Both are great pistols and the difference between the two is more about your interaction with it than the designs.
HK 45C?
Well pdx225? How do you like it? I've got the H&K P30 9mm. Nice gun. Still would take the PX4 over the H&K.