Join the #1 community for gun owners of the Northwest
We believe the 2nd Amendment is best defended through grass-roots organization, education, and advocacy centered around individual gun owners. It is our mission to encourage, organize, and support these efforts throughout Oregon, Washington, Idaho, Montana, and Wyoming.
Already a member? Log InFree Membership Benefits
Fewer ads
Discuss firearms and all aspects of firearm ownership
Join others in organizing against anti-gun legislation
Buy, sell, and trade in our classified section
Find nearby gun shops, ranges, training, and other resources
Discover free outdoor shooting areas
Stay up to date on firearm-related events
Share photos and video with other members
...and much more!
Discuss firearms and all aspects of firearm ownership
Join others in organizing against anti-gun legislation
Buy, sell, and trade in our classified section
Find nearby gun shops, ranges, training, and other resources
Discover free outdoor shooting areas
Stay up to date on firearm-related events
Share photos and video with other members
...and much more!
opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use disorder, reversing opioid overdose, suppressing cough, and suppressing opioid induced constipation. Extremely potent opioids such as carfentanil are only approved for veterinary use. Opioids are also frequently used non-medically for their euphoric effects or to prevent withdrawal.
Side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria. Tolerance and dependence will develop with continuous use, requiring increasing doses and leading to a withdrawal syndrome upon abrupt discontinuation. The euphoria attracts recreational use, and frequent, escalating recreational use of opioids typically results in addiction. An overdose or concurrent use with other depressant drugs commonly results in death from respiratory depression.
Opioids act by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate both the psychoactive and the somatic effects of opioids. Opioid drugs include partial agonists, like the anti-diarrhea drug loperamide and antagonists like naloxegol for opioid-induced constipation, which do not cross the blood-brain barrier, but can displace other opioids from binding in those receptors.
Because of opioid drugs' reputation for addiction and fatal overdose, most are controlled substances. In 2013, between 28 and 38 million people used opioids illicitly (0.6% to 0.8% of the global population between the ages of 15 and 65). In 2011, an estimated 4 million people in the United States used opioids recreationally or were dependent on them. As of 2015, increased rates of recreational use and addiction are attributed to over-prescription of opioid medications and inexpensive illicit heroin. Conversely, fears about over-prescribing, exaggerated side effects and addiction from opioids are similarly blamed for under-treatment of pain.
View More On Wikipedia.org
Side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria. Tolerance and dependence will develop with continuous use, requiring increasing doses and leading to a withdrawal syndrome upon abrupt discontinuation. The euphoria attracts recreational use, and frequent, escalating recreational use of opioids typically results in addiction. An overdose or concurrent use with other depressant drugs commonly results in death from respiratory depression.
Opioids act by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate both the psychoactive and the somatic effects of opioids. Opioid drugs include partial agonists, like the anti-diarrhea drug loperamide and antagonists like naloxegol for opioid-induced constipation, which do not cross the blood-brain barrier, but can displace other opioids from binding in those receptors.
Because of opioid drugs' reputation for addiction and fatal overdose, most are controlled substances. In 2013, between 28 and 38 million people used opioids illicitly (0.6% to 0.8% of the global population between the ages of 15 and 65). In 2011, an estimated 4 million people in the United States used opioids recreationally or were dependent on them. As of 2015, increased rates of recreational use and addiction are attributed to over-prescription of opioid medications and inexpensive illicit heroin. Conversely, fears about over-prescribing, exaggerated side effects and addiction from opioids are similarly blamed for under-treatment of pain.
View More On Wikipedia.org
-
‘Gas Station Heroin’ Is Causing Intense Withdrawals. It’s Legal in Most States.
A drug called tianeptine, known colloquially as "gas station heroin," has been banned by several states. It's being marketed as a dietary supplement, but some users are describing it as a highly addictive opioid. Tianeptine is a tricyclic antidepressant used to treat depression in some... -
Opioid deaths pass 70,000
Not a fan of the new york times generally. Good article, though. First paragraph they note that opioids killed more in 2017 than guns, which surprised me, because I wouldn't expect a Bloomberg rag to print a truth. Bleak New Estimates in Drug Epidemic: A Record 72,000 Overdose Deaths in 2017 -
Gabapentin - go-to drug for addicts in search of a stronger high
Confirmed by a friend who is a Pharmacist in British Columbia: We have people using and abusing gabapentin here. Some must be put on restricted dispensing schedules, such as monthly, weekly or even daily dispense to prevent them from over using. Health officials are sounding the alarm on a...
