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State Road 500 (SR 500) is a state highway running through Florida as a mostly unsigned route under several U.S. Highways. From Chiefland to Williston it is U.S. Highway 27 Alternate (US 27 Alt.). From Williston to Ocala, it is US 27. From Ocala to Holopaw, it is US 441. From Kissimmee to Indialantic it is US 192.

Names for State Road 500 include Young Boulevard, 100th Street, Hathaway Avenue, Noble Avenue, Blichton Road, 10th Street, Pine Street, Abshier Boulevard, North Boulevard, Main Street, Burleigh Boulevard, Orange Blossom Trail, East Irlo Bronson Memorial Highway, Space Coast Parkway, New Haven Avenue the Melbourne Causeway and Fifth Avenue.

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