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The .45 Schofield, also referred to as .45 Smith & Wesson is a revolver cartridge developed by Smith & Wesson for their S&W Model 3 Schofield top-break revolver. It is similar to the .45 Colt round though shorter and with a slightly larger rim, and will generally work in revolvers chambered for that cartridge; the converse is not true, since the .45 Colt case is longer. US government arsenals supplied .45 Schofield cartridges for the Schofield revolver and the Colt Army revolver to simplify their armament needs.

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