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Uridine monophosphate synthase (UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) is the enzyme that catalyses the formation of uridine monophosphate (UMP), an energy-carrying molecule in many important biosynthetic pathways. In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13).

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