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protac
A proteolysis targeting chimera (PROTAC) is a heterobifunctional small molecule composed of two active domains and a linker capable of removing specific unwanted proteins. Rather than acting as a conventional enzyme inhibitor, a PROTAC works by inducing selective intracellular proteolysis. PROTACs consist of two covalently linked protein-binding molecules: one capable of engaging an E3 ubiquitin ligase, and another that binds to a target protein meant for degradation. Recruitment of the E3 ligase to the target protein results in ubiquitination and subsequent degradation of the target protein by the proteasome. Because PROTACs need only to bind their targets with high selectivity (rather than inhibit the target protein's enzymatic activity), there are currently many efforts to retool previously ineffective inhibitor molecules as PROTACs for next-generation drugs.Initially described by Kathleen Sakamoto, Craig Crews and Ray Deshaies in 2001, the PROTAC technology has been applied by a number of drug discovery labs using various E3 ligases, including pVHL, Mdm2, beta-TrCP1, cereblon, and c-IAP1. Yale University licensed the PROTAC technology to Arvinas in 2013-14.
Price if firm, no trades. Brand new. Sportsman Warehouse charged me for too many, I was going to ship back but since they are correctly out of stock (pretty much always are with these), I figured I'd sell it locally for what I paid for it. If you want it shipped, you must pay for shipping, since...
Everything is in great shape. been to the range once, then back in the safe. The Thorntail mount is not included. I take PayPal gift, or you cover the fees. Post "I'll take it", them email for best response.