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New York State Route 357 (NY 357) is a 14.02-mile-long (22.56 km) state highway in New York, running from NY 7 in the Otsego County village of Unadilla to NY 28 in the Delaware County town of Franklin.
NY 357 is only briefly in Otsego County, crossing the Susquehanna River as it enters Delaware County for its duration. After passing through the village of Franklin, it ends at NY 28 south of Oneonta.

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