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Maryland Route 65 (MD 65) is a state highway in the U.S. state of Maryland. Known for most of its length as Sharpsburg Pike, the state highway runs 11.75 miles (18.91 km) from MD 34 in Sharpsburg north to the southern end of Hagerstown, where the highway continues north as Potomac Street toward the downtown area. MD 65 connects central and southern Washington County and serves as the primary access point to Antietam National Battlefield. The state highway, which was originally laid out as a turnpike, was constructed in its modern form in the mid-1920s. MD 65 was rebuilt in the early 1950s and relocated through Antietam National Battlefield by the early 1980s.

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