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M-60 is an east–west state trunkline highway in the US state of Michigan. It runs from the Niles area at a junction with US Highway 12 (US 12) to the Jackson area where it ends at Interstate 94 (I-94). The trunkline passes through a mix of farm fields and woodlands, crosses or runs along several rivers and connects several small towns of the southern area of the state. The westernmost segment runs along divided highway while the easternmost section is a full freeway bypass of Jackson.
M-60 was originally designed in 1919 with the rest of the state highway system in Michigan. It ran roughly along its current route connecting downtown Niles to downtown Jackson. In the mid-1920s, the western end was extended to New Buffalo; since then several bypasses of the smaller towns along the highway were added. One of these bypasses resulted in the creation of an alternate route (Alternate M-60, Alt. M-60) through Concord; that route has since been decommissioned. When Niles was bypassed in the 1950s, a business loop (Business M-60, Bus. M-60) was created through town. After the western end was truncated to its current location, that business loop was converted to a business spur.

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