The following is a list of one-time characters from the American animated television comedy series The Simpsons.
Some of the characters have returned to the show, sometimes in brief speaking appearances, or just 'in the crowd' scenes. Other characters originally intended to be one-time characters have ended up becoming regular cast members, such as Cletus Spuckler, Luigi Risotto, Disco Stu, Groundskeeper Willie, Crazy Cat Lady, Cookie Kwan and Lindsey Naegle.
For purposes of this list, "one-time" means they were central to an episode one time. Some of the characters listed here have appeared in later episodes, but only briefly. The characters are sorted by episode.

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