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The .500 Jeffery is a big-game rifle cartridge that first appeared around 1920, and was originally introduced by the August Schuler Company, a German firm, under the European designation "12.7×70mm Schuler" or ".500 Schuler". When offered by the famed British outfitter W.J. Jeffery & Co, it was renamed the .500 Jeffery so as to be more palatable to British hunters and sportsmen following World War One.

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