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The .375 Ruger (9.5×65.5mm) is a rimless, standard-length rifle cartridge designed for the hunting of large dangerous game. It is designed to provide an increase in performance over the .375 H&H cartridge, yet to be chambered in a standard length action rifle. The cartridge was designed in partnership, by Hornady and Ruger. In 2007, it was released commercially and chambered in the Ruger Hawkeye African and the Ruger Hawkeye Alaskan rifles.

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