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This reminds me of the old school Skeeter Skelton self-defense load.148 gr Wad Cutters work best for me out of a 642 airweight. From this short a barrel to get an expanding bullet to work takes a +P+ velocity or a much lighter bullet to get enough velocity to open every time.
But if I were shooting a 3" or longer barrel I might change my mind. when you get to 4" of barrel the advantage is clearly on expanding bullets.
DR
HBWC with the hollow base "towards enemy" over a charge of Unique.