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The problem with drugs generally is they are too unpredictable. Generally the quickest way to kill a vertebrate mammal is to sever the spinal cord just below the medulla oblongata that disrupts the autonomous nervous system. This has the effect of stopping blood from pumping, and respiration will also cease almost immediately. The trauma of such an event will blind the senses and death follows in seconds.

Drugs generally work by disrupting the nervous system and suppressing either breathing or heartbeat, the original "lethal cocktail" used for lethal injection was a high powered sedative followed by potassium chloride, which would cause the heart to relax to the point that it wasn't really beating any more. The newer "one drug" cocktail they've been using omits the potassium however different people have different tolerances and alergies to opiates so you may suppress someone's breathing, without giving them the euphoric effect, or without disrupting the circulatory system, meaning they simply suffocate under the weight of their diaphram.

Realistically, california's old gas chamber was simple, very effective, and fast, it was also cheap and relied on simple industrial chemistry, the europeans had no say in whether they were going to supply us with the drugs or not because you could pick up the stuff to kill someone in this fashion on the way to the execution at the local hardware store.
I could argue that a double barrel 12 gauge, point blank, to the head is a pretty quick way to end thing's.
 

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