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I converted my Smith 4506 to 45 SuperI used to use 45 Super and 450 SMC back when I only had 2 handguns. (Sig P220SAO and Para Ordnance 1911). A 24lb recoil spring ran them as well as my defensive ammo just fine in the PO.
Sprinco built a recoil managment system for it
it will still shoot 45 ACP for range work
have a couple boxes of Underwood 185gn 45 Super for serious work, but a little overkill for our home defense needs