My wife carries a 442 loaded with Hornady Critical Defense .38, 110gr (not +P). Pros: She can shoot it well at 7 yards. Simple to operate. Both practice and self defense ammunition (that she likes) is easy to find and relatively affordable. It's light, so she can carry it even wearing summer attire. Because it's light, she will always have a firearm with her no matter what. Cons: The most obvious is limited capacity and slower reloading. It's a little punishing for her even with standard pressure .38 ammo. Though she would shoot heavier grain bullets or even +P if she had to. But her follow-ups would be slower, and accuracy would suffer some. All that said, she really likes her Ruger SP101 2.25 inch barrel in a holster at 3 o'clock. But, depending on what she's doing, the lighter, smaller 442 is a nice option for her.