I CHOSE a .410 Circuit Judge "shotty" for my wife to defend her position in our back office. It has an 18.5" barrel, takes 3" .410 shells, and has a revolving cylinder with 5 shots. She can no longer rack a slide (on a handgun) and the weapon has no controls to defeat her efforts, and can get off shots faster than a pump gun. The office opens around a corner into the living room area so the distance is perfect for Winchester .410 PDX1 defense loads (I don't think you want to get shot with one)
This makes perfect sense, is a good use case for the gun, ammo, and user, and I applaud your efforts to sufficiently arm your wife despite her physical condition.