.45LC is mild in it (Federal American Eagle Ammo 45 Colt (Long Colt) 225 Grain Jacketed (https://www.midwayusa.com/product/144977/federal-american-eagle-ammunition-45-colt-long-colt-225-grain-jacketed-soft-point-box-of-50)) - as well it should be with that heavy of a gun - almost 4 pounds - and a comp to boot. The SA trigger is so smooth that when it breaks it is a surprise - perfect! .460 Mag - that's a handful. I don't have heavy bullet loads - the gun came with Hornady 200 gr. FTX at 2200 fps (from an 8") and you know you've touched it off when you shoot it. But those loads are not punishing - the 240 gr. .44 loads (special or mag.) are worse in my 329 PD and the hot heavy 275 and 300 magnum bear protection loads are punishing enough that most people don't want to shoot more than one much less a cylinder full. So the weight and the comp do make a significant difference. The flame from the comp with magnum loads is impressive, and that is during the day. There was a vid on Myth Busters where they used a .460V revolver to test whether it could cut your thumb off if you placed your thumb beside the cylinder/barrel gap, and they confirmed that it would (using chicken flesh).