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making a accurate humane kill shot comes with Practice. If you Accurately hit the animal both 7mm and 300 will put the animal down. Bullet placement is critical always along with bullet penetration both Calibers have good Penetration due to the great selection of bullets on the market today. I don't think you can go wrong with either caliber if you found a 7mm at a good price go for it and later you find a 300 at a good price get it then or Vice versa. Just my thoughts.