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State Route 42 (SR 42) is a decommissioned state highway in the southern region of the U.S. state of California, running along Manchester Avenue, Manchester Boulevard and Firestone Boulevard in Los Angeles and the cities south of it. After 1968, it ran from State Route 1 west of Inglewood (near Los Angeles International Airport) east to Interstate 5 in Norwalk. Though signed as SR 42, it was officially Route 105 until it was replaced by the parallel Interstate 105 on October 14, 1993. The entire route was deleted from the California Freeway and Expressway System in 2000, with the remaining portion of SR 42 being relinquished to local jurisdictions in that year, but the route is still occasionally signed as SR 42.

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