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P22 can refer to:
P22 phage, a bacteriophage virus that infects bacteria
P22 phosphor, a common phosphor used in CRTs
Walther P22, a semi-automatic pistol manufactured by Walther Sportwaffen
P22 type foundry, a digital type foundry that creates fonts
P-22, the National Park Service designation of a mountain lion known to inhabit Griffith Park in southern California
and also :
a Latvian first class State road

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