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C2orf22 (chromosome2 open reading frame 22) is a gene in humans that encodes the protein SLC66A3. C2orf22 is more commonly known as SLC66A3 (Solute Carrier Family 66 Member 3) or PQLC3 (PQ-loop repeat containing 3). The function of the SLC66A3 protein is not yet well understood but belongs to a family of five evolutionarily related proteins, the SLC66 lysosomal amino acid transporters. SLC66A3 is localized to the endoplasmic reticulum and has four transmembrane domains.

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